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Chiral Compounds : Chiral cyanohydrin derivatives
Nippon Shokubai has established a new commercial production technology for chiral cyanohydrin and its derivatives. We can supply many useful chiral cyanohydrin derivatives as pharmaceutical intermediates on the scale more than ton scale.
1. Enzymatic Synthesis of Chiral Cyanohydrin
R
1
:
aliphatic, aromatic, heterocyclic
R
2
:
H, aliphatic, aromatic, heterocyclic
R-HNL
:
R-cyanohydrin synthesizing enzyme ((
R
)-hydroxynitrile lyase)
S-HNL
:
S-cyanohydrin synthesizing enzyme ((
S
)-hydroxynitrile lyase)
2. Chemical Modification of Chiral Cyanohydrin
3. Chiral Cyanohydrin Derivatives
R
1
:
H, Cl, F, OH, CH
3
R
2
:
aliphatic
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