{"id":2308,"date":"2022-07-28T10:45:53","date_gmt":"2022-07-28T01:45:53","guid":{"rendered":"http:\/\/shokubai.mediawars.ne.jp\/ja\/?post_type=products&#038;p=2308"},"modified":"2026-03-13T16:57:04","modified_gmt":"2026-03-13T07:57:04","slug":"micocell","status":"publish","type":"products","link":"https:\/\/www.shokubai.co.jp\/en\/products\/detail\/micocell\/","title":{"rendered":"3D Cell Culture Vessel: MicoCell\u2122"},"content":{"rendered":"\n<div class=\"wp-block-my-gutenberg-my-block00 m_ancNav\"><ul class=\"anc_content\"><li><a href=\"#anc01\">Features and Properties\n<\/a><\/li><li><a href=\"#anc02\">Examples of Use\n<\/a><\/li><li><a href=\"#anc03\">Cautions<\/a><\/li><li><a href=\"#anc04\" title=\"\">Leaflet<\/a><\/li><\/ul><\/div>\n\n\n\n<figure class=\"wp-block-video\"><video controlslist=\"nodownload\" oncontextmenu=\"return false;\" controls src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/11\/materials09_2.mp4\"><\/video><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"anc01\">Features and Properties\n<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"726\" height=\"551\" src=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2025\/01\/micocell_1-1.png\" alt=\"\" class=\"wp-image-15934\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2025\/01\/micocell_1-1.png 726w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2025\/01\/micocell_1-1-300x228.png 300w\" sizes=\"(max-width: 726px) 100vw, 726px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Advantages<\/h4>\n\n\n\n<p>Formation of cell aggregates attached to substrate<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>(Cell aggregates) expected to be highly functional because they are in a similar state to that in the body<\/li>\n\n\n\n<li>Easy medium exchange<\/li>\n<\/ul>\n\n\n\n<p>Non-biological material is used<br>Cell aggregates can be collected without enzymatic processing<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cell aggregates can be collected together with cell products<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Characteristics<\/h4>\n\n\n\n<p>Formation of suspension cell aggregates<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Easy to lose cells during medium exchange<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Characteristics<\/h4>\n\n\n\n<p>Cultured cells are in a completely different state from that in the body.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Difficult to express cells&#8217; original function<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"649\" height=\"263\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/11\/mate09_2.jpg\" alt=\"\" class=\"wp-image-10625\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/11\/mate09_2.jpg 649w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/11\/mate09_2-300x122.jpg 300w\" sizes=\"(max-width: 649px) 100vw, 649px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"anc02\">Examples of Use\n<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Vessels Examples\n<\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"424\" height=\"159\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_003.jpg\" alt=\"\" class=\"wp-image-2655\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_003.jpg 424w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_003-300x113.jpg 300w\" sizes=\"(max-width: 424px) 100vw, 424px\" \/><figcaption class=\"wp-element-caption\">Various types of vessels are under development.\n<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Culture Examples\n<\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">Human adipose-derived stem cells <\/h4>\n\n\n\n<figure class=\"wp-block-video\"><video controlslist=\"nodownload\" oncontextmenu=\"return false;\" controls src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/11\/materials09-1.mp4\"><\/video><\/figure>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"260\" height=\"181\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_004.jpg\" alt=\"\" class=\"wp-image-2656\"\/><figcaption class=\"wp-element-caption\">It is possible to produce large quantities of adhering cell aggregates with a uniform particle size.\n<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"728\" src=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_01.png\" alt=\"\" class=\"wp-image-10920\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_01.png 760w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_01-300x287.png 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><\/figure>\n<\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"260\" height=\"195\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_006.jpg\" alt=\"\" class=\"wp-image-2659\"\/><figcaption class=\"wp-element-caption\">The cell aggregates can be collected without the use of release agents (enzymatic processing).\n<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"924\" src=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_02.png\" alt=\"\" class=\"wp-image-10921\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_02.png 760w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_02-247x300.png 247w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><figcaption class=\"wp-element-caption\">Higher undifferentiated marker production potency can be maintained, compared with two-dimensional cultures and three-dimensional suspension cultures.\n<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Rat Primary Hepatocytes\n<\/h4>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-4 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"724\" src=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_03.png\" alt=\"\" class=\"wp-image-10922\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_03.png 760w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_03-300x286.png 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"282\" height=\"205\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/11\/mate09_9.jpg\" alt=\"\" class=\"wp-image-10629\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Liver Cancer Cells (HepG2)\n<\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"288\" height=\"235\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/11\/mate09_10.jpg\" alt=\"\" class=\"wp-image-10630\"\/><figcaption class=\"wp-element-caption\">The data is provided by Professor Hiroyuki Ijima from the Graduate School of Engineering, Kyushu University.<\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Cell Aggregates Containing Vascular Structures\n<\/h4>\n\n\n\n<p>Co-culture of adipose-derived stem cells and vascular endothelial cells (HUVEC)\n<br>\u2022 Forming a dome-shaped blood vessel in the vertical direction from the adhesive substrate surface\n<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-5 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"250\" height=\"190\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_007.jpg\" alt=\"\" class=\"wp-image-2660\"\/><figcaption class=\"wp-element-caption\">Vascular structure viewed from the top<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"220\" height=\"190\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_008.jpg\" alt=\"\" class=\"wp-image-2662\"\/><figcaption class=\"wp-element-caption\">Vascular structure viewed from the side<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"210\" height=\"190\" src=\"\/en\/wordpress\/wp-content\/uploads\/2022\/07\/img_materials09_013.jpg\" alt=\"\" class=\"wp-image-2651\"\/><figcaption class=\"wp-element-caption\">Vascular structure viewed from the bottom<br> (Blue indicates cell nuclei)<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p>\u2022 Vascular structure improves hypoxia (state of low oxygen) in cell aggregates\n<\/p>\n\n\n\n<figure class=\"wp-block-image size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"272\" src=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_04-300x272.png\" alt=\"\" class=\"wp-image-10923\" srcset=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_04-300x272.png 300w, https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2022\/12\/micocell_en_04.png 760w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-element-caption\">Fumiaki Shima, Tomomi Makino, Fabrication of Spheroids with Dome-Shaped Endothelial Tube Networks by an Adhesive Culture System, Adv. Biosyst. 4 (10), 2020, 2000120.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-flexible-table-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>Item\n<\/th><th>Features\n<\/th><th>Advantages\n<\/th><\/tr><tr><th rowspan=\"3\">Vessel Properties\n<\/th><td>No use of biologically-derived components and materials\n<\/td><td>Possible to create cultures that do not contain biologically-derived components and materials\n<\/td><\/tr><tr><td>Flat bottom, high transparency, no surface treatment\n<\/td><td>Clear observation with phase contrast and fluorescence microscopes\n<\/td><\/tr><tr><td>High-density cavity structure\n<\/td><td>Possible to produce large quantities of cell aggregates with a uniform particle size (several hundred to 40,000 or more)\n<\/td><\/tr><tr><th rowspan=\"2\">Culture Properties<\/th><td>Formation of cell aggregates that are moderately attached to the bottom of the vessel\n<\/td><td>Reduces loss of cell aggregates during culture medium exchange, enables long-term culturing, and is easy to carry\n<\/td><\/tr><tr><td>Cell aggregates can be collected without the use of release agents (enzymatic processing)<\/td><td>Easy operation, low toxicity, cell products such as extracellular matrix\n<\/td><\/tr><tr><th>Cells Functions<\/th><td>Maintains a good survival rate and protein production<\/td><td>Applications in drug screening, regenerative medicine, etc.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"anc03\">Cautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>This is a product we are currently developing.<br>It is not a medical device, but a physical and chemical device for laboratory research.<\/li>\n\n\n\n<li>The data listed in this page are examples, and are not guarantees of the performance of this product.<\/li>\n\n\n\n<li>Please note that the contents and MicoCell\u2122 specifications listed on this page may be changed without prior notice.<\/li>\n\n\n\n<li>Please be aware of the intellectual property rights related to third-party usage, usage methods, etc. when using the Nippon Shokubai product(s) listed in this website page. The Company does not take any responsibility whatsoever for any issues that may arise in relation to these intellectual property rights. <\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"anc04\">Leaflet<\/h2>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.shokubai.co.jp\/en\/wordpress\/wp-content\/uploads\/2026\/03\/micocell_leaflet_en.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">PDF Download<\/a><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Features and Properties Advantages Formation of cell aggregates attached to substrate Non-biological material  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"cat_products":[329],"class_list":["post-2308","products","type-products","status-publish","format-standard","hentry","cat_products-uses_08_01_06"],"aioseo_notices":[],"acf":{"products_common_name":"","products_main_uses":"Cell therapy, Regenerative medicine, Toxicity assay, Drug screening, Modeling of cancer and organs, etc.","products_same_series":"","products_same_uses":"","is_dev_products":true,"memo":"\u753b\u50cf\u65e5\u672c\u3042\u308a\u3000\u4e0a\u7530","show_hreflang":["ja"]},"_links":{"self":[{"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/products\/2308"}],"collection":[{"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/products"}],"about":[{"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/types\/products"}],"author":[{"embeddable":true,"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":35,"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/products\/2308\/revisions"}],"predecessor-version":[{"id":19928,"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/products\/2308\/revisions\/19928"}],"wp:attachment":[{"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/media?parent=2308"}],"wp:term":[{"taxonomy":"cat_products","embeddable":true,"href":"https:\/\/www.shokubai.co.jp\/en\/wp-json\/wp\/v2\/cat_products?post=2308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}