In development Biocompatible Polymer – Nippon Shokubai’s Intermediate Water Polymer
- Applications
Basic Information
| RX-6-GH-30（in development） | ||
|---|---|---|
| Appearance | Colorless and transparent | |
| Solid | 30 ％（aqueous） | |
| Viscosity | 1000 ｍPas | |
| Toxicity and Safety | Ames Test: Negative（5000μg/plate） Cytotoxicity: None (IC50 ＞５000μg/mL) Skin Sensitization: Negative (Test concentration: 100% (v/v); Positive rate: 0%) | |
| Wet adhesion (after curing) | polyester | excellent |
| nylon | good | |
| vinyl cloride | excellent | |
| sus（304） | poor | |
| Al | poor | |
| glass | good | |
Features and Properties
- Exhibits excellent biocompatibility due to a high content of intermediate water and a low proportion of non-freezing water.
- Forms coatings that combine hydrophilicity and water resistance when used in combination with crosslinking agents
- Demonstrates excellent blood compatibility.
Platelet inactive, Complement inactive, Nonhemolytic
Prevents blood coagulation over extended periods. - Suppresses protein adsorption.
- Inhibits the adhesion of microorganisms (bacteria).
- Cell adhesion can be controlled by selecting appropriate formulations.
Enables both antithrombogenicity and cell adhesion to be achieved simultaneously.
Examples of Applications
- Coating agent for medical devices
- Cell culture substrate
- Cell tissue scaffolding material
- Cancer diagnostic kit
Key Features and Properties Data
– High content of intermediate water and a low proportion of non-freezing water
RX-6-GH-30 has as much intermediate water as PVP. The ratio of non-freezing water to intermediate water is as small as PMEA.
Based on the intermediate water analysis, GH-30 is presumed to have superior biocompatibility compared to PVP and PMEA, which are already in practical use as antithrombotic polymers.
– Excellent Antithrombogenic property
It inhibits platelet adhesion and prevents platelet activation.
【Platelet-rich plasma／Leave for 1hr】
– Suppresses protein adsorption
① GH-30 inhibits the adsorption of blood proteins.
② GH-30 inhibits the adsorption of various proteins with different surface charges.
– Inhibits the adhesion of microorganisms (bacteria)
It suppresses the adhesion of bacteria that cause food poisoning and tooth decay, as well as biofilm-forming bacteria.
– Lubricant Coating
GH crosslinked coating film has a certain degree of water resistance and forms a surface with excellent lubricity in wet conditions.
Load 400gf, Speed 1000mm/min
Sus plate(1㎝×1cm)
Distance 20mm
In water 100cycle
TL201Tt (Trinity-Lab. Inc.)
https://trinity-lab.com/
GH coating has excellent durability, maintaining low friction resistance even after 100 cycles of sliding.
Disclaimer
- With respect to this development product, Nippon Shokubai makes no warranties of any kind, including, without limitation, any warranty that its use does not infringe the intellectual property rights of any third party, and shall not be liable for any issues or damages arising from such use.
- As this product is a development product, please independently assess its compliance with applicable laws, regulations, standards, and guidelines related to its intended use.
- This page presents examples of material property data and research and evaluation results, and does not guarantee the performance, efficacy, or safety of this material or this development product.
- This material is not a pharmaceutical or medical device and is not intended to be sold for use in specific medical applications.
- The contents (and specifications) described on this page are subject to change without prior notice.